Table 5 Artesunate Tmax values obtained following oral artesunate administration.

[23]

15 healthy Cambodian male adults

4 mg/kg AS once with mefloquine

0.75^a

[6]

8 healthy adults in Australia

150 mg AS once

0.65 (n = 6)^a

[24]

20 healthy adult males in Australia

200 mg/day × 3 days alone (Period 1); repeated with mefloquine after washout (Period 2)

Period 1/Day 1: 0.6^b

Period 1/Day 3: 0.6^b

Period 2/Day1: 0.5^b

Period 2/Day 3: 0.6^b

[25]

6 healthy adults in Geneva

200 mg AS once

0.25 (5/6 subjects)

0.5 (1/6 subjects)

[26]

23 healthy Malaysian adults

200 mg AS once with amodiaquine as fixed or non-fixed product

Fixed:0.26

Non-fixed:0.53

[27]

13 healthy adults in Africa

Mean dose: 4.26 mg/kg with (ACT) or without (AS only) amodiaquine as single dose

AS only: 0.62

ACT: 0.86

[28]

8 healthy male Thai adults

300 mg AS (Guilin or Arenco formulation)

Guilin: 0.25^a

Arenco: 0.31^a

[29]

10 healthy male Vietnamese adults

200 mg AS once daily × 5 days

Day 1: 0.8^a

Day 5: 0.8^a

[30]

12 healthy male Malaysian adults

200 mg AS once

0.66 ± 0.34

[31]

11 male Thai adults with uncomplicated falciparum malaria

200 mg AS once, followed by 100 mg 12 hours later, then 100 mg once daily for another 4 days

Acute: 0.5^a

Convalescence:1.0^a

[32]

43 adults with uncomplicated falciparum malaria in Thailand

AS+mefloquine as fixed (200 mg AS) or nonfixed (4 mg/kg AS) combination

Fixed:0.833 (n = 19)

Nonfixed:0.925 (n = 23)

[33]

13 male and female adult patients in the DRC with acute uncomplicated falciparum malaria

200 mg AS once daily × 3 days with amodiaquine

1.4 (n = 10)

[34]

86 acute uncomplicated falciparum malaria patients from Malawi and Gambia

1, 2, or 4 mg/kg AS with chlorproguanil and dapsone once daily × 3 days

1 mg/kg: 1.08^a

2 mg/kg: 0.55^a

4 mg/kg: 1.03^a

[35]

6 male Thai adults with uncomplicated falciparum malaria and 6 healthy male adults

100 mg AS once

Healthy: 0.71

Patients: not determined

[36]

57 children (2-14 years) with uncomplicated falciparum malaria in Gabon

AS dose (mg/kg/day) with pyronaridine

Group A:2.1(1.4-2.4)

Group B:3.3(2.4 - 3.9)

Group C:4.8(3.0 - 6.1)

Group D: 3.8(3.0-4.3)

Group A:0.6

Group B:0.7

Group C:1.0

Group D:0.5

[37]

40 children and adults with uncomplicated falciparum malaria in Pailin, Cambodia and 40 adults with uncomplicated falciparum malaria in Wang Pha, Thailand

At each site:

Group 1: AS monotherapy: 2 mg/kg/day × 7 days

Group 2: AS 4 mg/kg/day × 3 days + mefloquine

Thailand:

Group 1: 0.38^a

Group 2: 0.50^a

Cambodia:

Group 1:0.50^a

Group 2: 1.00^a