Table 6 Artesunate half-life values following oral artesunate administration.

[29]

10 healthy male Vietnamese adults

200 mg once daily × 5 days

Day 1: 0.43^a

Day 5: 0.50^a

[30]

12 healthy male Malaysian adults

200 mg single dose

0.49

[28]

8 healthy male Thai adults

300 mg AS (Guilin or Arenco formulation)

Guilin:0.53

Arenco:0.57

[26]

23 healthy Malaysian adults

200 mg AS + amodiaquine as fixed or non-fixed product

Fixed:0.63

Non-fixed:0.76

[34]

86 acute uncomplicated falciparum malaria patients from Malawi and Gambia

1, 2, or 4 mg/kg AS + chlorproguanil and dapsone once daily × 3 days

1 mg/kg: 0.515^b

2 mg/kg: 0.478^b

4 mg/kg: 0.467^b

[31]

11 male Thai adults with uncomplicated falciparum malaria

200 mg AS once, followed by 100 mg 12 hours later, then 100 mg once daily × 4 days

Acute: 0.36^a

Convalescence: 0.54^a

[35]

6 male Thai adults with uncomplicated falciparum malaria and 6 healthy male adults

100 mg AS once

Healthy: 0.41

Patients: not determined

[36]

57 children (2-14 years) with uncomplicated falciparum malaria in Gabon

AS dose (mg/kg) with pyronaridine

Group A:2.1(1.4-2.4)

Group B:3.3(2.4 - 3.9)

Group C:4.8(3.0 - 6.1)

Group D: 3.8(3.0-4.3)

Group A: 0.8 (n = 12)

Group B:1.1 (n = 12)

Group C:0.5 (n = 10)

Group D:1.2 (n = 13)

[37]

40 children and adults with uncomplicated falciparum malaria in Pailin, Cambodia and 40 adults with uncomplicated falciparum malaria in Wang Pha, Thailand

At each site:

Group 1: AS monotherapy: 2 mg/kg/day × 7 days

Group 2: AS 4 mg/kg/day × 3 days + mefloquine

Thailand:

Group 1: 0.37^a

Group 2: 0.58^a

Cambodia:

Group 1: 0.29^a

Group 2: 0.29^a