Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration

Table 9 Summary of AS pharmacokinetic results following rectal AS administration.

Ref.	Subjects & Regimen	Cmax (ng/mL)	Tmax (hours)	Half-life (hours)	AUC (ng*hr/mL)
[49] Sirivichay et al, 2007	16 paediatric patients with uncomplicated falciparum malaria 10 mg/kg (n = 7) or 20 mg/kg (n = 9) AS as rectal suppositories	507; 561†^a	0.8; 1.0^a	0.9; 0.9^a	692; 1076†^a
[50] Halpaap et al, 1998	12 paediatric patients with uncomplicated falciparum malaria 50 mg AS as rectal suppository [0.86 - 2.55 mg/kg AS]	90†	0.58
[30] Navaratnam et al, 1998	12 healthy Malaysian adults 200 mg AS as rectal suppository	448.5	1.43	0.95	796

Estimates from PopPK studies are described in the text. Values given as mean unless otherwise specified.
†Units converted to uniform scale a. Median

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