Compound | Average Anti-malarial Activity**(ng/ml) | IC50 (μM) | Average Cytotoxicity** (ng/ml) | Therapeutic Index | Average Tanimoto Coefficient |
---|---|---|---|---|---|
GR-M001 | > 10'000* | > 20.0 | ND | NA | 0.170 |
GR-M002 | 5381 | 12.54 | ND | NA | 0.162 |
GR-M003 | > 10'000 | > 20.0 | ND | NA | 0.148 |
GR-M004 | 4778 | 10.28 | ND | NA | 0.175 |
GR-M005 | 9736 | 18.91 | ND | NA | 0.147 |
GR-M006 | 1634 | 3.520 | ND | NA | 0.175 |
GR-M007 | 446 | 0.999 | 10420 | 23 | 0.186 |
GR-M008 | 382 | 1.027 | > 90'000 | > 236 | 0.124 |
GR-M009 | 13 | 0.027 | > 90'000 | > 6923 | 0.159 |
GR-M010 | 172 | 0.332 | 4860 | 28 | 0.183 |
GR-M011 | 86 | 0.185 | 3250 | 38 | 0.159 |
GR-M012 | 168* | 0.328 | 89770 | 533 | 0.145 |
Anti-malarial control (chloroquine) | 4.2 | 0.013 | NA | ~2 | ND |
Cytotoxicity control (Podophyllotoxin) | NA | NA | 9.5 | NA | NA |