Table 2 Sulphadoxine pharmacokinetic parameters (Median [IQR]) in Malian children under five with uncomplicated falciparum malaria, by treatment group

Sulphadoxine dose (mg/kg)

27.8

(25.0-27.8)

28.8

(25-31.3)

27.8

(25-28.8)

0.46

Median Concentration day 1

[IQR] (μg/mL)

73.20

[66.55-89.33]

80.95

[65.05-89.08]

76.80

[62.70-93.50]

0.86

Median Concentration day 3

[IQR] (μg/mL)

61.3

[47.8-73.0]

63.9

[49.6-72.7]

57.9

[47.4-69.8]

0.71

Median Concentration day 7

[IQR] (μg/mL)

35.25

[27.38- 41.70]

34.95

[28.60-40.85]

33.40

[24.63-44.05]

0.97

Median AUC [IQR]

(μg/mL.day)

660.08

[520.37-832.11]

682.67

[579.45-797.12]

672.04

[525.35-898.86]

0.88

Median VD [IQR]

(mL/kg)

349.35

[295.43-434.25]

345.60

[294.15-427.95]

357.80

[266.70-427.40]

0.97

Median T1/2 [IQR]

(days)

5.60 [4.62-6.78]

5.77 [5.11-6.45]

6.13 [4.90-7.26]

0.56

Median Clearance [IQR] (mL/kg/day)

41.85

[35.13-54.78]

41.65

[34.20-52.83]

41.00

[32.10-53.40]

0.80