Table 3 Pyrimethamine pharmacokinetic parameters (Median [IQR]) in Malian children under five with uncomplicated falciparum malaria, by treatment group
PARAMETERS | SP arm | SP+AQ arm | SP+AS arm | P-value [Kruskal-Wallis] |
|---|---|---|---|---|
Pyrimethamine dose (mg/kg) | 1.39 (1.25-1.56) | 1.44 (1.25-1.56) | 1.39 (1.25-1.44) | 0.46 |
Median Concentration day1 [IQR] (ng/mL) | 259.50 [212.50-337.50] | 300.50 [220.00-339.25] | 274.00 [235.00-312.00] | 0.55 |
Median Concentration day 3 [IQR] (ng/mL) | 155 [127-187] | 174 [132-215] | 158 [119-191] | 0.14 |
Median Concentration day 7 [IQR] (ng/mL) | 56.75 [46.40-92.95] | 58.75 [43.60-98.60] | 59.60 [42.45-86.63] | 0.85 |
Median AUC [IQR] (ng/mL.day) | 1307.45 [1087.59-1773.94] | 1405.32 [1110.36-2016.49] | 1363.76 [1193.71-1765.91] | 0.46 |
Median VD [IQR] (L/kg) | 4.65 [3.93-6.40] | 4.00 [3.03-5.43] | 5.60 [4.40-7.20] | 0.001 |
Median T1/2 [IQR] (days) | 3.26 [2.74-3.82] | 2.78 [2.24-3.65] | 4.02 [3.05-4.85] | 0.0016 |
Median Clearance [IQR] (L/kg/day) | 1.10 [0.80-1.38] | 1.00 [0.70-1.30] | 1.00 [0.80-1.20] | 0.38 |