Event | Normal (αα/αα) | Heterozygotes (-α/αα) | Homozygotes (-α/-α) | |||
---|---|---|---|---|---|---|
All episodes of malaria | ||||||
Incidence (n/child-years) | 3.10 | (812/262) | 2.89 | (622/215) | 2.83 | (136/48) |
Hazard ratio, crude | 1.00 | Reference | 0.93 | [0.80-1.06] | 0.92 | [0.73-1.14] |
Hazard ratio, adjusted † | 1.00 | Reference | 0.93 | [0.82-1.06] | 0.91 | [0.73-1.14] |
Episodes with parasitaemia > 5,000/μL (1,249) | 1.00 | Reference | 0.94 | [0.81-1.10] | 0.89 | [0.67-1.17] |
Episodes with parasitaemia > 10,000/μL (1,119) | 1.00 | Reference | 0.95 | [0.81-1.11] | 0.91 | [0.68-1.22] |
Episodes with parasitaemia > 100,000/μL (263) | 1.00 | Reference | 0.94 | [0.69-1.29] | 0.98 | [0.57-1.69] |
Episodes with haemoglobin concentration < 80 g/L (178) | 1.00 | Reference | 1.25 | [0.86-1.84] | 2.65 | [1.71-4.10] |
1 st episodes of malaria | ||||||
Incidence (n/child-years) | 3.08 | (257/84) | 2.66 | (199/75) | 3.44 | (49/14) |
Incidence rate ratio | 1.00 | Reference | 0.86 | [0.71-1.04] | 1.12 | [0.81-1.52] |
Hazard ratio, crude | 1.00 | Reference | 0.90 | [0.75-1.09] | 1.10 | [0.81-1.49] |
Hazard ratio, adjusted † | 1.00 | Reference | 0.89 | [0.74-1.08] | 1.06 | [[0.78-1.44] |
All episodes of non-malarial fever | ||||||
Incidence (n/child-years) | 1.64 | (431/262) | 1.72 | (370/215) | 1.82 | (87/48) |
Hazard ratio, crude | 1.00 | Reference | 1.04 | [0.85-1.28] | 1.10 | [0.82-1.49] |
Hazard ratio, adjusted ¶ | 1.00 | Reference | 1.00 | [0.84-1.19] | 0.98 | [0.73-1.36] |
All hospital admissions or deaths § | ||||||
Incidence (n/child-years) | 0.15 | (39/262) | 0.10 | (21/215) | 0.19 | (9/48) |
Hazard ratio, crude | 1.00 | Reference | 0.66 | [0.38-1.14] | 1.26 | [0.56-2.89] |
Hazard ratio, adjusted ¶ | 1.00 | Reference | 0.57 | [0.33-0.98] | 0.89 | [0.36-2.24] |