Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques

Table 2 Geometric means of antibody titres as determined by ELISA.

	All PkAMA1	Protected PkAMA1	Not protected PkAMA1	All PkMSP1₁₉	Protected PkMSP1₁₉	Not protected PkMSP1₁₉
Post vaccination	2,305 [855-6,214]	2,417 [469-12,451]	2,137 [508-8,990]	332 [97-1,136]	633 [109-3,671]	118 [16-853]
Post challenge	79,030 [46,803-133,444]	94,870 [40,055-224,699]	59,000 [32,980-105,548]	16,784 [11,104-25,369]	17,875 [11,730-27,240]	15,175 [4,562-50,477]

In brackets the 95% confidence intervals. No significant differences were observed between protected or not-protected groups of animals. For both antigens and all groups, antibody levels are significantly higher after challenge.

ISSN: 1475-2875