Figure 4From: Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screeningSensitivity of transgenic Plasmodium berghei expressing Pv DHFR-TS enzyme to pyrimethamine (A), chloroquine (B) and artesunate (C). The transgenic parasites were validated using the standard four-day suppressive test. Percent parasite inhibition was plotted for groups of at least five mice orally given varying doses of pyrimethamine, chloroquine and artesunate. Data were shown as mean ± S.D. of at least three independent experiments.Back to article page