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Figure 4 | Malaria Journal

Figure 4

From: Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

Figure 4

Sensitivity of transgenic Plasmodium berghei expressing Pv DHFR-TS enzyme to pyrimethamine (A), chloroquine (B) and artesunate (C). The transgenic parasites were validated using the standard four-day suppressive test. Percent parasite inhibition was plotted for groups of at least five mice orally given varying doses of pyrimethamine, chloroquine and artesunate. Data were shown as mean ± S.D. of at least three independent experiments.

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