Figure 1
From: Use of mefloquine in children - a review of dosage, pharmacokinetics and tolerability data
Plasma levels during chemoprophylaxis in children. The Figure shows the simulated plasma levels of mefloquine expected to be achieved in a child weighting 13 kg who received an initial dose of 125 mg of mefloquine and then 16 weekly prophylaxis doses of 62.5 mg mefloquine (equivalent to the currently recommended ¼ tablet for this weight category of child). Mefloquine concentrations of 620 ng/mL (= 1.67 μmol/L) are considered to be effective against Plasmodium falciparum in the bloodstream.