Table 3 Older studies prior to year 2000 documenting mefloquine use in children
From: Use of mefloquine in children - a review of dosage, pharmacokinetics and tolerability data
Malaria treatment studies Author/Reference | Age (in years) | No. of children treated with mefloquine | Location of the study |
|---|---|---|---|
Tin F et al. [26] Single dose treatment of falciparum malaria with mefloquine: field studies with different doses in semi-immune adults and children in Burma. Bull WHO 60, 913-917, 1982 | 5-12 | 89 | Myanmar |
Chongsuphajaisiddhi T. et al. [27] A phase-III clinical trial of mefloquine in children with chloroquine-resistant falciparum malaria in Thailand. Bull WHO 65, 223-226, 1987 | 5-12 | 82 | Thailand |
Guo X.B. [28] Double-blind dose finding study of mefloquine-sulfadoxine-pyrimethamine in children with acute falciparum malaria. Trans Roy Soc Trop Med & Hyg 82: 538-540, 1988 | 5-15 | 60 | China |
Sowunmi A. et al. [29] Clinical efficacy of mefloquine in children suffering from chloroquine-resistant Plasmodium falciparum malaria in Nigeria. Transactions of the Royal Society of Tropical Medicine & Hygiene, 84, 761-764, 1990 | 0.5-11 | 62 | Nigeria |
Trinh T.K. [30] Double-blind studies with mefloquine alone and in combination with sulfadoxine-pyrimethamine in 120 adults and 120 children with falciparum malaria in Vietnam. Trans Roy Soc Trop Med & Hyg 84, No 1, 50-53, 1990 | 6-12 | 80 | Vietnam |
Slutsker L.M. et al. [31] Mefloquine therapy for Plasmodium falciparum malaria in children under 5 years of age in Malawi: in vivo/in vitro efficacy and correlation of drug concentration with parasitological outcome. Bulletin of the World Health Organization 68, 53-59, 1990. | < 5 | 121 | Malawi |
Nosten F. et al. [32] Mefloquine-resistant falciparum malaria on the Thai-Burmese border. Lancet 337, 1140-1143, 1991. | < 15 | 245 | Thai-Myanmar border |
Sowunmi A. et al. [33] Evaluation of the relative efficacy of various antimalarial drugs in Nigerian children under five years of age suffering from acute uncomplicated falciparum malaria. Annals of Tropical Medicine and Parasitology 86, 1-8, 1992. | < 5 | 100 | Nigeria |
Sowunmi A. et al. [34] The relationship between the response of Plasmodium falciparum malaria to mefloquine in African children and its sensitivity in vitro. Trans Roy So Trop Med & Hyg 86, 368-371, 1992 | 4-12 | 85 | Nigeria |
Ter Kuile F. et al. [21] High-dose mefloquine in the treatment of multidrug-resistant falciparum malaria. Journal of Infectious Diseases 166, 1393-1400, 1992. | < 15 | 117 | Thai- Myanmar border |
Ter Kuile F. et al [35] Halofantrine versus mefloquine in treatment of multi-drug resistant falciparum malaria. Lancet; 341:1044-1049, 1993 | < 15 | 95 | Thai - Myanmar border |
Smithuis F.M. [36] Comparison of two mefloquine regimens for treatment of Plasmodium falciparum malaria on the north eastern Thai-Cambodian border. Antimicrobial agents and chemotherapy, 37, No 9, 1977-1981, 1993 | < 15 | 27 | Thai-Cambodian border |
Piarroux R. [37] Choice of therapy for imported cases of falciparum malaria in children: a retrospective study of 100 cases seen in Marseilles, France. Trans Roy Soc Trop Med & Hyg 87 No 1, 72-74, 1993 | < 15 | 12 | Imported paediatric malaria in France |
Luxemburger C. et al. [38] Single day mefloquine-artesunate combination in the treatment of multi-drug resistant falciparum malaria. Trans Roy Soc Trop Med & Hyg, 88, 213-217, 1994. | < 15 | 237 | Thai-Myanmar border |
Sowunmi A. et al. [39] Open comparison of mefloquine, MSP and chloroquine in acute uncomplicated falciparum malaria in children. Trans Roy Soc Trop Med & Hyg, 89, 303-305, 1995. | 0.5-10 | 43 | Nigeria |
Ter Kuile F. et al. [40] Predictors of mefloquine treatment failure: a prospective study of 1590 patients with uncomplicated falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 89, 660-664, 1995. | < 15 | 752 | Thai- Myanmar border |
Ter Kuile F. et al. [19] Mefloquine treatment of acute falciparum malaria: a prospective study of non-serious adverse effects in 3673 patients. Bulletin World Health Organization 73, 631-642, 1995. | < 14 | 1319 | Thai- Myanmar border |
Radloff PD. et al. [41] Arteflene compared with mefloquine for treating Plasmodium falciparum malaria in children. American Journal of Tropical Medicine and Hygiene, 55, 259-262, 1996 | 7-12 | 21 | Gabon |
Sowunmi A. et al. [42] Open comparison of artemether and mefloquine in uncomplicated Plasmodium falciparum hyperparasitaemia in children. Annals of Tropical Paediatrics 16, 5-9, 1996 | 1-10 | 43 | Nigeria |
Price RN. [43] Artesunate/mefloquine treatment of multi-drug resistant falciparum malaria. Trans Roy Soc Trop Med & Hyg 91 573-577, 1997 | < 14 | 1453 | Thai-Myanmar Border |
Ranford-Cartwright LC. et al. [44] Molecular analysis of recrudescent parasites in a Plasmodium falciparum drug efficacy trial in Gabon. Trans Roy Soc Trop Med & Hyg 91, 719-724, 1997 | < 15 | 64 | Gabon |
Okoyeh J.N. [45] Responses of multidrug-resistant Plasmodium falciparum parasites to mefloquine in Nigerian children. Trop Med Int Health, 2, No 4, 319-324, 1997 | 0.5-7 | 33 | Nigeria |
Lell B.et al. [46] Malaria chemotherapy trial at a minimal effective dose of mefloquine-sulfadoxine-pyrimethamine compared with equivalent doses of Sulfadoxine/Pyrimethamine or Mefloquine alone. Am J Trop Med Hyg 58, No 5, 619-624, 1998 | < 15 | 76 | Gabon |
Luxemburger C. et al. [47] Early vomiting of mefloquine in children with malaria is not modified by the timing of antipyretic treatment. Trans Roy Soc Trop Med & Hyg, 92, 562-563, 1998 | 2-15 | unclear | Thai- Myanmar border |