Table 4 International guidelines showing the importance of mefloquine (MQ) for the chemoprophylaxis of malaria

WHO International Travel and Health [1]

Mefloquine recommended for chemoprophylaxis for children weighting > 5 kg. Dosage 5 mg/kg/week

Treatment of uncomplicated malaria in children weighing > 5 kg. Dosage 25 mg/kg as split dose (15 mg/kg followed by 10 mg/kg 6-24 hours apart)

DTG [48]

Deutsche Tropenmed. Gesellschaft

http://www.dtg.org/uploads/media/Malaria_2010.pdf

Mefloquine recommended for chemoprophylaxis for children weighing > 5 kg. Dosage 5 mg/kg/week

No longer routinely recommended for SBET

Canadian Guidelines

CATMAT[49]

Mefloquine recommended for chemoprophylaxis in travellers > 5 kg body weight (5 mg/kg once weekly)-start 3 weeks before travel

Not routinely recommended for SBET

5-10 kg 1/8 Tablet

10-20 kg ¼ Tablet

20-30 kg 1/2 Tablet

30-35 kg ¾ Tablet

> 45 kg 1 tablet

CDC [50]

Begin 1-2 weeks before travel

Not routinely recommended for SBET

≤ 9 kg (5 mg/kg salt once weekly)

> 9 kg-19 kg ¼ Tablet once weekly

> 19-30 kg 1/2 Tablet once weekly

> 31-45 kg ¾ Tablet once weekly

> 45 kg 1 Tablet once weekly

UK Guidelines [51]

Weekly mefloquine

Not routinely recommended for SBET

< 6 kg not recommended

6-9.9 kg ¼ Tablet weekly

10-15.9 kg ¼ Tablet weekly

16-24.9 kg 1/2 Tablet weekly

25-44.9 kg ¾ Tablet weekly

45 kg and over 1 Tablet weekly

French Guidelines [53]

Mefloquine 5 mg/kg per week.

Not routinely recommended for SBET

Start 10 days before travel, take throughout the exposure period and for 3 weeks thereafter

< 15 kg not recommended

15-19 kg: ¼ Tablet weekly

19-30 kg: 1/2 Tablet weekly

30-45 kg: ¾ Tablet weekly