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Figure 1 | Malaria Journal

Figure 1

From: A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in Gabon

Figure 1

Haplotype analysis of resistant and sensitive parasites. The two most frequent local resistant haplotypes from the year 1995/6 are displayed. One of the haplotypes is identical to the FCR3 haplotype and represented 21% of all haplotypes analysed in 1995/6. The other haplotype (denoted "Lamba") represented 37% of all haplotypes in 1995/6. The haplotypes of the three sensitive monoinfections SP15, SP21 and TDU28 from the years 2005 - 7 are represented in the lower part of the figure. Alleles identical to the local resistant haplotypes are shaded in light grey, differing alleles in dark grey. Samples SP21 and TDU28 carry completely different chromosome 7 haplotypes, suggesting that they represent reintroduced sensitive parasites. In contrast SP15 carries the same alleles as the local resistant haplotypes at the microsatellite PE14D and B5M77 and subsequently starts to diverge. This suggests a backcross of the sensitive pfcrt allele. Sequencing of the marker 9B12 in the sensitive isolate SP21 was unsuccessful. Haplotypes are represented by indicating the number of repeats at each microsatellite. The pfcrt haplotype at codons 72-76 is also displayed.

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Malaria Journal

ISSN: 1475-2875

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