Table 1 Ex vivo susceptibility of 93 Plasmodium falciparum isolates from Dakar to chloroquine (CQ), monodesethylamodiaquine (MDAQ), lumefantrine (LMF), dihydroartemisinin (DHA), quinine (QN), mefloquine (MQ) and doxycycline (DOX)
| Â | Â | Isolate IC50 | Ratio (Isolate IC50 /Mean 3D7 IC50) | ||||||
|---|---|---|---|---|---|---|---|---|---|
Drug | No | Mean | CI95% | Min | Max | Mean | CI95% | Min | Max |
CQ | 83 | 34.8 nM | 26.9-45.0 | 4.6 | 1324 | 2.1 | 1.6-2.7 | 0.26 | 81.7 |
MDAQ | 83 | 15.7 nM | 12.8-19.4 | 1.5 | 82.8 | 0.8 | 1.6-2.7 | 0.07 | 3.9 |
LMF | 79 | 21.3 nM | 17.1-26.6 | 1.5 | 150 | 0.8 | 0.6-1.0 | 0.05 | 5.8 |
DHA | 88 | 1.6 nM | 1.3-1.8 | 0.1 | 9.4 | 0.9 | 0.7-1.0 | 0.05 | 7.3 |
QN | 82 | 159 nM | 128-197 | 6.4 | 1291 | 1.2 | 1.0-1.5 | 0.06 | 8.6 |
MQ | 88 | 29.8 nM | 24.3-36.5 | 3.0 | 170 | 0.5 | 0.4-0.7 | 0.05 | 3.0 |
DOX | 76 | 11.6 μM | 9.5-14.2 | 0.5 | 48.1 | 1.1 | 0.9-1.4 | 0.04 | 4.7 |