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Figure 6 | Malaria Journal

Figure 6

From: Sexual recombination is a signature of a persisting malaria epidemic in Peru

Figure 6

Model illustrating the clonal backbone of single-clone infections (A) and homogenization between constituents of complex infections (B). Each vertical column of circles represents a specific microsatellite locus (seven total for both A and B) and the number of independent circles within each vertical column represents the number of alleles detected within that particular locus. Blue and yellow coloring is indicative of a correlation with either Mad20 (blue) or K1 (yellow) Pf msp1-Block2 main allelic families, respectively. The size of the colored circles represents the number of infections indentified by a particular allele that was associated with either Mad20 or K1. When circles are superimposed, this shows that alleles were correlated (with varying proportions based on circle-size) to both Mad20 and K1. Lines between loci indicate the number of instances (differentiated by the line thickness) that one allele paired with another allele in the population. A) Illustrates the clonal backbone present within single-clone infections, indicated by having a predominantly blue (Mad20) clonal family and a predominately yellow (K1) clonal family. This is further supported by a fewer number of lines between loci pairs and predominantly clonal haplotypes. B) Illustrates a breakdown in linkage between loci pairs, with an increased number of loci pairs and a relatively equal distribution of clones correlated to each Pf msp1-B2 main allelic family causing the disappearance of the clonal backbone.

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