Impact of combining intermittent preventive treatment with home management of malaria in children less than 10 years in a rural area of Senegal: a cluster randomized trial

Table 2 Impact of IPTc combined to HMM on malaria incidence in the two groups

	Malaria incidence Rate/100 person-month (95% CI)	Unadjusted IRR (95% CI)	Adjusted IRR (95% CI)	Protective efficacy (%) (95% CI)	p value*
Interventions
HMM	35.5 [25.0-50.3]	1	1
HMM + IPTc	07.1 [1.1- 9.5]	0.20 [0.04-1.0]	0.21[0.04-0.90]	79 [10; 96]	0.04
Gender
Female	21.0 [11.1-44.3]	1	1
Male	22.4 [11.6-48.3]	1.06 [0.62-1.84]	1.18 [0.74-1.86]	-18[-86;26]	0.48
Age groups
1 years	17.3 [10.1-32.8]	1	1
[2 - 5 years]	28.5 [13.8-66.3]	1.62 [0.84-3.10]	1.50[0.85-2.65]	-50[-165;15]	0.16
[6- 10 years]	17.4 [09.8-32.8]	1.0[0.74-1.34]	0.98[0.74-1.27]	2 [-27; 26]	0.85

HMM home-based management; HMM+IPTc home-based management+intermitent preventive treatment; IRR incidence rate ratio. Intraclass correlation coefficients for Gender:0.01, age group:0.007. *All p value are adjusted for clustering by robust standard errors.

ISSN: 1475-2875