Figure 1

Structure of the ADAMTS13 gene and LD plot. A, ADAMTS13 protein (1427 amino acids) consisting of a signal peptide (S), a propeptide (P), a metalloprotease domain (Met), a disintegrin-like domain (Dis), a thrombospondin type-1 (TSP-1) repeat (1), a cysteine-rich domain (Cys), a spacer domain (Spa), seven additional TSP-1 repeats (2-8), and two complement C1r/C1s, Uegf, Bmp1 (CUB) domains. B, ADAMTS13 gene comprising 29 exons on the human chromosome 9q34. C, LD plot among 15 SNPs with minor allele frequency of more than 0.05 in the Asian HapMap populations (JPT + CHB). Five tagSNPs and rs1055432 analysed in Thai malaria patients are indicated by arrows. A pairwise r² value is shown in each square. Darker shading indicates higher r² value and black shading indicates r² of 1.