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Table 2 Allele frequencies of ADAMTS13 SNPs in Thai malaria patients

From: Association of ADAMTS13 polymorphism with cerebral malaria

SNP

Allele frequency

Association P-value

M (2n = 734)

S (2n = 452)

C (2n = 230)

M vs C

S vs C

M + S vs Ca

rs2301611;

      

T

691 (0.94)

430 (0.95)

223 (0.97)

   

C

43 (0.06)

22 (0.05)

7 (0.03)

0.12

0.32

0.14

HWE P-value

0.23

0.44

0.74

   

rs3118667;

      

T

523 (0.71)

297 (0.66)

163 (0.71)

   

C

211 (0.29)

155 (0.34)

67(0.29)

0.93

0.19

0.64

HWE P-value

0.74

0.31

0.73

   

rs739469;

      

C

525 (0.72)

298 (0.66)

160 (0.70)

   

G

209 (0.28)

154 (0.34)

70 (0.30)

0.56

0.34

1.0

HWE P-value

0.41

0.26

0.88

   

rs652600;

      

T

470 (0.64)

273 (0.60)

152 (0.66)

   

C

264 (0.36)

179 (0.40)

78 (0.34)

0.58

0.16

0.33

HWE P-value

0.14

0.32

0.25

   

rs4962153;

      

G

689 (0.94)

431 (0.95)

226 (0.98)

   

A

45 (0.06)

21 (0.05)

4 (0.02)

0.0057b

0.082

0.012c

HWE P-value

0.14

0.44

0.84

   

rs1055432;

      

C

516 (0.70)

293 (0.65)

160 (0.70)

   

A

218 (0.30)

159 (0.35)

70 (0.30)

0.87

0.23

0.76

HWE P-value

0.16

0.76

0.55

   
  1. Note; HWE, Hardy-Weinberg equilibrium; M, mild malaria; S, non-cerebral severe malaria; C, cerebral malaria.
  2. a Since the frequency of rs4962153-A was different between mild and cerebral malaria groups, the frequency was further compared between non-cerebral (mild and non-cerebral severe malaria groups) and cerebral malaria groups.
  3. b OR = 0.27; 95% CI = 0.096-0.76; Permutation P-value = 0.041.
  4. c OR = 0.30; 95% CI = 0.11-0.83; Permutation P-value = 0.074.