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Table 3 AL dosing and pharmacokinetic parameters in patients weighing 5 to < 10 kg or 10 to < 15 kg

From: Similar efficacy and safety of artemether-lumefantrine (Coartem®) in African infants and children with uncomplicated falciparum malaria across different body weight ranges

 

Body weight

 

5 to < 10 kg

10 to < 15 kg

Artemether & dihydroartemisinin (DHA)

  

Dispersible tablet

N = 171

N = 352

Total dose artemether (mg/kg)

14.8 ± 2.57

10.0 ± 1.30

Cmax artemether (ng/mL)

372 ± 251

110 ± 97.7

Cmax DHA (ng/mL)

107 ± 76.6

38.2 ± 42.4

Crushed tablet

N = 183

N = 37

Total dose artemether (mg/kg)

14.7 ± 1.94

10.0 ± 1.28

Cmax artemether (ng/mL)

295 ± 214

137 ± 111

Cmax DHA (ng/mL)

89.9 ± 83.5

36.6 ± 28.7

Lumefantrine

  

Dispersible tablet

N = 24

N = 78

Total dose lumefantrine (mg/kg)

90.4 ± 9.46

60.4 ± 7.37

Cmax (μg/mL)

6.55

5.55

AUC0-last (μg·h/mL)

550

393

Crushed tablet

N = 26

N = 75

Total dose lumefantrine (mg/kg)

88.6 ± 13.1

59.5 ± 6.87

Cmax (μg/mL)

5.50

6.29

AUC0-last (μg·h/mL)

578

558

  1. Data are mean ± SD;1 N = 18 for DHA;2 N = 34 for DHA;3 N = 19 for DHA