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Table 3 AL dosing and pharmacokinetic parameters in patients weighing 5 to < 10 kg or 10 to < 15 kg

From: Similar efficacy and safety of artemether-lumefantrine (Coartem®) in African infants and children with uncomplicated falciparum malaria across different body weight ranges

  Body weight  
5 to < 10 kg 10 to < 15 kg
Artemether & dihydroartemisinin (DHA)   
Dispersible tablet N = 171 N = 352
Total dose artemether (mg/kg) 14.8 ± 2.57 10.0 ± 1.30
Cmax artemether (ng/mL) 372 ± 251 110 ± 97.7
Cmax DHA (ng/mL) 107 ± 76.6 38.2 ± 42.4
Crushed tablet N = 183 N = 37
Total dose artemether (mg/kg) 14.7 ± 1.94 10.0 ± 1.28
Cmax artemether (ng/mL) 295 ± 214 137 ± 111
Cmax DHA (ng/mL) 89.9 ± 83.5 36.6 ± 28.7
Lumefantrine   
Dispersible tablet N = 24 N = 78
Total dose lumefantrine (mg/kg) 90.4 ± 9.46 60.4 ± 7.37
Cmax (μg/mL) 6.55 5.55
AUC0-last (μg·h/mL) 550 393
Crushed tablet N = 26 N = 75
Total dose lumefantrine (mg/kg) 88.6 ± 13.1 59.5 ± 6.87
Cmax (μg/mL) 5.50 6.29
AUC0-last (μg·h/mL) 578 558
  1. Data are mean ± SD;1 N = 18 for DHA;2 N = 34 for DHA;3 N = 19 for DHA