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Table 4 Efficacy outcomes by body weight group

From: Similar efficacy and safety of artemether-lumefantrine (Coartem®) in African infants and children with uncomplicated falciparum malaria across different body weight ranges

Efficacy outcomes

Body weight

5 to < 10 kg

10 to < 15 kg

15 to < 25 kg

25 to < 35 kg

14-day PCR curea

    

   n/N

140/143

334/334

277/277

58/58

   %

97.9

100.0

100.0

100.0

   95% CI (%)

94.0-99.6

97.9-100.0

98.7-100.0

90.8-100.0

28-day PCR curea

    

   n/N

139/143

330/334

271/277

57/58

   %

97.2%

98.8%

97.8%

98.3%

   95% CI (%)

93.0-99.2%

97.0-99.7%

95.3-99.2%

90-8-100.0%

42-day PCR curea

    

   n/N

123/129

284/290

227/237

50/53

   %

95.3

97.9

95.8

94.3

   95%

90.2-98.3

95.6-99.2

92.4-98.0

84.3-98.8

Kaplan Meier estimates of parasite clearance time, hb

    

   N

164

371

288

63

   Median

35.6

35.0

25.8

25.8

   Interquartile range

24.0-36.1

23.9-36.1

23.8-35.9

23.9-35.7

   Mean (SE)

35.0 (1.2)

32.8 (1.0)

31.7 (1.1)

30.8 (1.6)

Kaplan Meier estimates of fever clearance time, hb

    

   N

164

369

288

63

   Median

8.2

7.8

7.8

7.7

   Interquartile range

7.7-35.0

7.5-23.6

7.6-23.4

7.4-8.5

   Mean (SE)

44.4 (9.1)

26.5 (3.5)

30.5 (6.4)

11.5 (1.4)

  1. a mITT populationb ITT population