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Table 4 Efficacy outcomes by body weight group

From: Similar efficacy and safety of artemether-lumefantrine (Coartem®) in African infants and children with uncomplicated falciparum malaria across different body weight ranges

Efficacy outcomes Body weight
5 to < 10 kg 10 to < 15 kg 15 to < 25 kg 25 to < 35 kg
14-day PCR curea     
   n/N 140/143 334/334 277/277 58/58
   % 97.9 100.0 100.0 100.0
   95% CI (%) 94.0-99.6 97.9-100.0 98.7-100.0 90.8-100.0
28-day PCR curea     
   n/N 139/143 330/334 271/277 57/58
   % 97.2% 98.8% 97.8% 98.3%
   95% CI (%) 93.0-99.2% 97.0-99.7% 95.3-99.2% 90-8-100.0%
42-day PCR curea     
   n/N 123/129 284/290 227/237 50/53
   % 95.3 97.9 95.8 94.3
   95% 90.2-98.3 95.6-99.2 92.4-98.0 84.3-98.8
Kaplan Meier estimates of parasite clearance time, hb     
   N 164 371 288 63
   Median 35.6 35.0 25.8 25.8
   Interquartile range 24.0-36.1 23.9-36.1 23.8-35.9 23.9-35.7
   Mean (SE) 35.0 (1.2) 32.8 (1.0) 31.7 (1.1) 30.8 (1.6)
Kaplan Meier estimates of fever clearance time, hb     
   N 164 369 288 63
   Median 8.2 7.8 7.8 7.7
   Interquartile range 7.7-35.0 7.5-23.6 7.6-23.4 7.4-8.5
   Mean (SE) 44.4 (9.1) 26.5 (3.5) 30.5 (6.4) 11.5 (1.4)
  1. a mITT populationb ITT population