Skip to main content

Table 1 In vitro susceptibility and Pfnhe-1 polymorphisms of the 74 Plasmodium falciparum isolates from the Republic of Congo

From: In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo

Isolates Cpm
without drug
Cpm
With highest QN
concentration
QN IC50 No DNNND repeat No NHNDNHNNDDD
repeat
No genotype profile
16517 23404 1440 1097 3 2 ms4760-27
16612 49650 8273 888 1 2 ms4760-3
16520 6512 1077 882 1 2 ms4760-3
16094 2007 620 862 2 1 ms4760-24
16980 2151 980 782 2 2 ms4760-33
17267 2558 455 776 2 2 ms4760-1
16631 1807 282 750 1 2 ms4760-3
16698 1263 353 740 2 1 ms4760-6
16960 2011 714 689 2 2 ms4760-1
16958 19732 861 645 3 2 ms4760-30
16983 3710 943 627 3 2 ms4760-1
16957 19773 1300 615 1 2 ms4760-29
16966 2264 545 604 2 2 ms4760-31
16941 18540 1175 576 1 2 ms4760-3
16991 2804 815 567 1 1 ms4760-36
16953 5675 1249 564 1 2 ms4760-12
16539 44532 4112 537 1 2 ms4760-3
17250 6558 606 506 1 2 ms4760-3
16942 10927 1163 502 1 2 ms4760-3
16959 9886 914 488 2 2 ms4760-1
17008 2151 961 482 1 2 ms4760-35
16986 2302 624 481 2 2 ms4760-1
16968 8477 962 457 2 2 ms4760-1
17249 1276 412 408 1 2 ms4760-22
17216 3179 539 404 1 2 ms4760-38
17253 9717 1091 396 2 1 ms4760-6
16987 7232 938 388 3 1 ms4760-15
16349 28606 2048 377 3 1 ms4760-25
17231 3545 389 354 1 2 ms4760-39
16518 8912 1361 351 3 1 ms4760-7
16955 9379 1188 346 3 2 ms4760-27
17211 6451 655 346 1 2 ms4760-3
16695 27421 2316 341 1 2 ms4760-3
16996 1347 597 340 2 2 ms4760-34
17208 18356 1208 335 1 2 ms4760-3
16536 6617 847 333 2 2 ms4760-1
16365 4631 724 332 1 2 ms4760-22
16979 7449 990 326 2 2 ms4760-18
17202 11053 929 319 1 2 ms4760-3
16364 12210 1990 316 2 2 ms4760-26
16331 8912 1113 314 3 2 ms4760-9
15868 1530 498 309 1 2 ms4760-22
16610 4063 961 305 3 1 ms4760-7
16535 16007 1274 291 3 1 ms4760-15
16323 43074 5859 290 1 2 ms4760-12
16992 9464 1111 276 1 2 ms4760-12
17237 12385 873 269 1 2 ms4760-3
17305 21667 1398 269 2 2 ms4760-3
16305 11269 917 265 1 2 ms4760-3
17303 18553 1646 264 2 2 ms4760-1
17212 2755 520 259 1 2 ms4760-3
16304 16194 738 254 2 2 ms4760-1
17241 5758 447 254 1 2 ms4760-3
16970 2359 705 247 1 1 ms4760-32
16995 7642 1004 247 2 2 ms4760-1
17210 11018 1370 244 1 2 ms4760-22
17233 12100 956 231 2 1 ms4760-6
17265 1593 238 226 2 2 ms4760-1
17214 2421 316 224 2 2 ms4760-37
17209 3499 680 216 3 2 ms4760-9
17007 3633 1159 212 3 2 ms4760-9
16116 11417 999 204 2 2 ms4760-18
17201 25594 2530 204 1 1 ms4760-36
17304 24453 1982 199 2 2 ms4760-1
16086 10918 699 174 3 1 ms4760-15
17283 4391 315 146 3 2 ms4760-1
17010 2897 1103 141 3 2 ms4760-9
16117 17474 1291 121 2 2 ms4760-1
16078 1654 396 106 2 2 ms4760-1
16085 5229 707 86 2 1 ms4760-6
17301 39337 2016 84 1 2 ms4760-12
15867 6893 739 73 1 2 ms4760-3
16091 17320 1695 67 2 2 ms4760-1
16077 4539 353 36 1 2 ms4760-23
  1. Cpm = count per minute
  2. IC50 = Inhibitory concentration 50% in nM
  3. QN = quinine
  4. Pfnhe- 1 ms4760 microsatellite genotype profiles according to the GenBank