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Table 1 Biological functions perturbed following hyperoxia exposure on P. falciparum

From: Global response of Plasmodium falciparum to hyperoxia: a combined transcriptomic and proteomic approach

Functional groupa

Number of entitiesb

p-valuec

GPI anchor biosynthesis

29

0.0006

DNA repair

15

0.0072

Vacuolar acidification

11

0.0255

Actin filament organization

12

0.0296

Nucleosome assembly

12

0.0490

Regulation of cell shape

6

0.0519

Leading strand elongation

10

0.0533

Lysosomal H+ import

26

0.0589

Response to oxidative stress

17

0.0799

  1. aGene Set Enrichment Analysis (GSEA) using the Mann-Whitney-U-test enrichment algorithm in PathwayStudio software indicated functional groups significantly altered (p < 0.08). For each functional group, the bnumber of genes included and corresponding cp-values are listed.
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Malaria Journal

ISSN: 1475-2875

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