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Table 2 Mean % antibody depletion from FVO, HB3 and 3D7 AMA1-coated plates.

From: Immunization with different Pf AMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits

Coating antigen

Competitor antigen

Gp 1 (f3h) n = 5

Gp 2 (hf3) n = 6

Gp 3 (h3f) n = 4

Gp 4 (NA mix) n = 6

Gp5 (DiCo mix) n = 6

FVO AMA1

FVO

98.5 (97.3 - 99.7)

95.9 (95.1 - 96.8)

98.2 (96.3 - 100.1)

96.8 (95.4 - 98.2)

97.6 (96.4 - 98.7)

 

HB3

93.2 (88.1 - 98.3)

90.4 (87.0 - 93.8)

93.2 (86.0 - 100.4)

90.6 (87.4 - 93.9)

91.3 (89.7 - 92.9)

 

3D7

84.5 (77.5 - 91.5)

75.5 (74.3 - 76.7)

76.6 (65.4 - 87.8)

70.4 (64.7 - 76.0)

77.0 (69.4 - 84.7)

 

CAMP

78.7 (73.6 - 83.7)

70.3 (65.9 - 74.6)

74.2 (64.4 - 84.1)

70.3 (64.7 - 74.0)

84.0 (82.3 - 85.8)

HB3 AMA1

FVO

87.5 (79.0 - 96.0)

86.0 (81.2 - 90.9)

91.4 (89.3 - 93.6)

86.6 (83.3 - 89.9)

84.1 (80.6 - 87.5)

 

HB3

96.1 (93.6 - 98.5)

97.5 (95.4 - 99.6)

98.2 (98.1 - 98.4)

96.7 (95.0 - 98.4)

95.6 (93.7 - 97.4)

 

3D7

86.7 (82.3 - 91.0)

84.3 (75.9 - 92.8)

77.9 (70.5 - 85.4)

73.7 (66.7 - 80.6)

74.7 (70.5 - 78.9)

 

CAMP

76.8 (73.4 - 80.1)

68.5 (62.7 - 74.3)

74.4 (70.2 - 78.6)

66.8 (60.2 - 73.3)

81.2 (78.2 - 84.2)

3D7 AMA1

FVO

83.0 (75.3 - 90.8)

91.8 (86.7 - 97.0)

91.3 (84.8 - 97.9)

73.2 (66.1 - 80.3)

86.9 (84.4 - 89.4)

 

HB3

89.3 (85.2 - 93.4)

95.9 (92.7 - 99.1)

94.1 (89.2 - 99.0)

83.6 (76.1 - 91.1)

88.7 (86.2 - 91.2)

 

3D7

100.2 (96.8 - 103.7)

98.2 (95.9 - 100.2)

96.8 (94.6 - 99.0)

95.8 (94.3 - 97.4)

97.1 (95.2 - 99.0)

 

CAMP

79.5 (71.6 - 87.5)

82.0 (77.0 - 87.1)

85.7 (77.0 - 94.5)

71.0 (66.5 - 75.5)

89.2 (86.0 - 92.4)

  1. Values reported as mean (95% CI) per immunization group for the same competitor antigen on each coating antigen.