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Table 2 Sequence polymorphism in pfcrt

From: Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum

Isolate/clone CQ IC50(nM) Amino acid in pfcrt gene
72 73 74 75 76 198 220 271 326 356 371
3D7 8 C V M N K E A Q N I R
Dd2 48 C V I E T E S E S T I
BC1 76 C V I E T E S E S T I
BC7 54 C V I E T E S E S T I
BC12 49 C V I E T E S E S T I
BC22 42 C V I E T K* S E S T I
BC31 31 C V I E T K* S E S T I
BC35 57 C V I E T K* S E S T I
J1 107 C V I E T E S E S T I
J3 119 C V I E T E S E S T I
J4 114 C V I E T E S E S T I
J5 121 C V I E T E S E S T I
J6 167 C V I E T E S E S T I
J9 123 C V I E A** E S E S T I
KS14 67 C V I E T E S E S T I
KS21 68 C V I E T E S E S T I
KS28 74 C V I E T E S E S T I
KS33 55 C V I E T E S E S T I
KS50 78 C V I E T K* S E S T I
PCM2 75 C V I E T E S E S T I
PCM7 51 C V I E T E S E S T I
RN54 47 C V I E T E S E S T I
  1. * Glutamic acid = > Lysine
  2. ** Lysine == > Alanine