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Table 2 Sequence polymorphism in pfcrt

From: Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum

Isolate/clone

CQ IC50(nM)

Amino acid in pfcrt gene

72

73

74

75

76

198

220

271

326

356

371

3D7

8

C

V

M

N

K

E

A

Q

N

I

R

Dd2

48

C

V

I

E

T

E

S

E

S

T

I

BC1

76

C

V

I

E

T

E

S

E

S

T

I

BC7

54

C

V

I

E

T

E

S

E

S

T

I

BC12

49

C

V

I

E

T

E

S

E

S

T

I

BC22

42

C

V

I

E

T

K*

S

E

S

T

I

BC31

31

C

V

I

E

T

K*

S

E

S

T

I

BC35

57

C

V

I

E

T

K*

S

E

S

T

I

J1

107

C

V

I

E

T

E

S

E

S

T

I

J3

119

C

V

I

E

T

E

S

E

S

T

I

J4

114

C

V

I

E

T

E

S

E

S

T

I

J5

121

C

V

I

E

T

E

S

E

S

T

I

J6

167

C

V

I

E

T

E

S

E

S

T

I

J9

123

C

V

I

E

A**

E

S

E

S

T

I

KS14

67

C

V

I

E

T

E

S

E

S

T

I

KS21

68

C

V

I

E

T

E

S

E

S

T

I

KS28

74

C

V

I

E

T

E

S

E

S

T

I

KS33

55

C

V

I

E

T

E

S

E

S

T

I

KS50

78

C

V

I

E

T

K*

S

E

S

T

I

PCM2

75

C

V

I

E

T

E

S

E

S

T

I

PCM7

51

C

V

I

E

T

E

S

E

S

T

I

RN54

47

C

V

I

E

T

E

S

E

S

T

I

  1. * Glutamic acid = > Lysine
  2. ** Lysine == > Alanine
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Malaria Journal

ISSN: 1475-2875

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