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Table 3 DHA noncompartmental pharmacokinetic data in pregnant, postpartum, and non-pregnant women with Plasmodium falciparum infection.

From: Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC

 

Pregnant cases

 

P-value

Parameters

Ante-partum

Post-partum

(3 months)

Non-pregnant controls

Ante vs. Post*

Ante vs. Non-pregnant controls†

Post vs. Non-pregnant controls†

Cmax (ng/mL)

904.6

[363.9 - 2541.9]

979.5

[414.5 - 2246.3]

1284.7

[539.8 - 3259.4]

0.89

0.24

0.090

Tmax (h)

1.50

[0.25 - 6.00]

1.50

[0.50 - 4.00]

1.52

[0.50 - 4.03]

0.95

0.57

0.34

AUCall (ng*h/mL)

1730.5

[1034.7 - 4085.5]

2122.2

[1308.9 - 4054.9]

2787.0

[1244.8 - 6363.5]

0.0080

0.0018

0.021

AUCfree (ng*h/mL)

398.5

[138.7 - 663.9]

373.0

[186.5 - 708.3]

504.6

[197.9 - 1301.3]

0.80

0.057

0.043

CL/F (L/h)

85.5

[36.2 - 142.9]

69.7

[36.5 - 113.0]

53.1

[23.2 - 118.8]

0.0035

0.0018

0.021

CL/F (L/kg/h)

1.39

[0.75 - 2.46]

1.26

[0.63 - 2.32]

1.07

[0.53 - 1.89]

0.033

0.0025

0.011

T½ (h)

1.28

[0.83 - 2.71]

1.63

[0.92 - 2.18]

1.41

[0.86 - 6.55]

0.021

0.28

0.27

Vd/F (L)

157.4

[59.9 - 335.9]

158.3

[66.0 - 332.7]

128.2

[38.5 - 400.1]

0.82

0.098

0.071

Vd/F (L/kg)

2.84

[1.25 - 5.33]

3.00

[1.55 - 5.37]

2.45

[0.78 - 6.56]

0.54

0.17

0.083

FF

0.21

[0.13 - 0.31]

0.19

[0.11 - 0.27]

0.18

[0.09 - 0.39]

0.014

0.031

0.82

  1. Medians [range] and nonparametric comparison of groups
  2. * Wilcoxon signed rank test.
  3. † Wilcoxon rank sum test.