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Table 3 HPLC characteristics of lumefantrine related impurities

From: Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine

#

Compound

RT(1)

RRT(2)

Most abundant

m/z observed

1

Desbenzylketo N-oxide

1.79

0.08

436.14

2

Monodesbutyl derivative

3.25

0.15

474.00

3

Lumefantrine N-oxide

3.96

0.17

544.08

4

Desbenzylketo derivative

7.41

0.33

420.13

5

Desbenzyl derivative

7.69

0.34

406.09

6

Lumefantrine oxide

10.96

0.49

544.12

7

Lumefantrine oxide

11.45

0.52

544.12

8

Impurity A

12.70

0.58

528.10

9

Lumefantrine oxide

12.97

0.59

544.12

L

Lumefantrine

22.28

1.00

528.10

  1. (1) Retention time (min.)
  2. (2) Relative retention time