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Table 3 HPLC characteristics of lumefantrine related impurities

From: Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine

# Compound RT(1) RRT(2) Most abundant
m/z observed
1 Desbenzylketo N-oxide 1.79 0.08 436.14
2 Monodesbutyl derivative 3.25 0.15 474.00
3 Lumefantrine N-oxide 3.96 0.17 544.08
4 Desbenzylketo derivative 7.41 0.33 420.13
5 Desbenzyl derivative 7.69 0.34 406.09
6 Lumefantrine oxide 10.96 0.49 544.12
7 Lumefantrine oxide 11.45 0.52 544.12
8 Impurity A 12.70 0.58 528.10
9 Lumefantrine oxide 12.97 0.59 544.12
L Lumefantrine 22.28 1.00 528.10
  1. (1) Retention time (min.)
  2. (2) Relative retention time