Figure 5
From: Plasmodium berghei ANKA infection increases Foxp3, IL-10 and IL-2 in CXCL-10 deficient C57BL/6 mice
(A-C): Plasma levels of IL-2 in P. berghei ANKA infected and control CXCL-10-/- and wild type C57BL/6 mice. CXCL-10-/- and wild type C57BL/6 (n = 10) were infected with P. berghei ANKA parasitized blood intra-peritoneally. Control mice were injected with uninfected blood. Mice were sacrificed at day 2, 4 & 8. Plasma was collected from infected and uninfected mice and ELISA was performed to determine IL-2 levels using the R&D systems (MN USA). There was significant induction of IL-2 in CXCL-10-/- than in WT at day 2 (statistically significant, p < 0.05) and 4 post-infection. Differences between IL-2 levels in CXCL-10-/- and WT at day 8 were not significant (error bar on plot for day 8 CXCL-10-/- (KO) could be a potential outlier. It presence or removal did not affect the difference between the two group of mice during the analysis).