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Table 3 Genotype frequencies for the tlr-4, tlr-9 and tirap polymorphisms in P. falciparum-infected and non-infected subjects

From: Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients

   Genotype Frequency    
Gene
(Polymorphism)
Observed expected P
(HWE, X2)
OR
(95% CI)
P
value
   Genotype Non-infected No (%) Infected No (%) Non-infected No (%) Infected No (%)    
   W (D/D) 287 (89.7) 276 (86.3) 288 (90) 273 (85.3)   0.721 (0.446-1.166) 0.181
  D299G H (D/G) 33 (10.3) 39 (12.1) 31 (9.7) 45 (14.1) NI = 0.33
I = 0.013
1.161 (0.709-1.899) 0.553
tlr-4   M (GG) - 5 (1.6) 1 (0.3) 2 (0.6)   - -
   W (T/T) 270 (84.4) 271 (84.7) 272 (85) 273 (85.3)   1.024 (0.667-1.572) 0.913
  T399I H (T/I) 50 (15.6) 49 (15.3) 46 (14.4) 45 (14.1) NI = 0.125
I = 0.138
0.976 (0.636-1.499) 0.913
   M (I/I) - - 2 (0.6) 2 (0.6)   - -
   W (TT) 130 (40.6) 142 (44.4) 136 (42.5) 133 (41.6)   1.166 (0.852-1.596) 0.337
  T-1486C H (TC) 157 (49.1) 130 (40.6) 145 (45.3) 147 (45.9) NI = 0.149
I = 0.058
0.710 (0.520-0.971) 0.032
tlr-9   M (CC) 33 (10.3) 48 (15) 39 (12.2) 40 (12.5)   1.535 (0.956-2.464) 0.075
   W (TT) 270 (84.4) 276 (86.2) 258 (80.6) 273 (85.3)   1.162 (0.749-1.801) 0.503
  T-1237C H (TC) 35 (10.9) 39 (12.2) 59 (18.4) 45 (14.1) NI < 0.0001
I = 0.0135
1.130 (0.696-1.836) 0.621
   M (CC) 15 (4.7) 5 (1.6) 3 (1) 2 (0.6)   0.323 (0.116- 0.899) 0.023
   W (S/S) 235 (73.4) 210 (65.6) 238 (74.4) 218 (68.1)   0.691 (0.492-0.969) 0.032
tirap S180L H (S/L) 82 (25.6) 108 (33.8) 76 (23.7) 92 (28.8) NI = 0.150
I = 0.0025
1.479 (1.051-2.081) 0.024
   M (L/L) 3 (1) 2 (0.6) 6 (1.9) 10 (3.1)   0.665 (0.11-4.004) 0.653
  1. NI: non-infected
  2. I: P. falciparum- infected
  3. HWE: Hardy-Weinberg Equilibrium (P < 0.05)
  4. W: Wild type allele, H: Heterozygote allele, M: Mutant type allele
  5. OR: Odds ratios
  6. CI: Confidence interval