Table 3 Genotype frequencies for the tlr-4, tlr-9 and tirap polymorphisms in P. falciparum-infected and non-infected subjects

W (D/D)

287 (89.7)

276 (86.3)

288 (90)

273 (85.3)

0.721 (0.446-1.166)

0.181

D299G

H (D/G)

33 (10.3)

39 (12.1)

31 (9.7)

45 (14.1)

NI = 0.33

I = 0.013

1.161 (0.709-1.899)

0.553

tlr-4

M (GG)

-

5 (1.6)

1 (0.3)

2 (0.6)

-

-

W (T/T)

270 (84.4)

271 (84.7)

272 (85)

273 (85.3)

1.024 (0.667-1.572)

0.913

T399I

H (T/I)

50 (15.6)

49 (15.3)

46 (14.4)

45 (14.1)

NI = 0.125

I = 0.138

0.976 (0.636-1.499)

0.913

M (I/I)

-

-

2 (0.6)

2 (0.6)

-

-

W (TT)

130 (40.6)

142 (44.4)

136 (42.5)

133 (41.6)

1.166 (0.852-1.596)

0.337

T-1486C

H (TC)

157 (49.1)

130 (40.6)

145 (45.3)

147 (45.9)

NI = 0.149

I = 0.058

0.710 (0.520-0.971)

0.032

tlr-9

M (CC)

33 (10.3)

48 (15)

39 (12.2)

40 (12.5)

1.535 (0.956-2.464)

0.075

W (TT)

270 (84.4)

276 (86.2)

258 (80.6)

273 (85.3)

1.162 (0.749-1.801)

0.503

T-1237C

H (TC)

35 (10.9)

39 (12.2)

59 (18.4)

45 (14.1)

NI < 0.0001

I = 0.0135

1.130 (0.696-1.836)

0.621

M (CC)

15 (4.7)

5 (1.6)

3 (1)

2 (0.6)

0.323 (0.116- 0.899)

0.023

W (S/S)

235 (73.4)

210 (65.6)

238 (74.4)

218 (68.1)

0.691 (0.492-0.969)

0.032

tirap

S180L

H (S/L)

82 (25.6)

108 (33.8)

76 (23.7)

92 (28.8)

NI = 0.150

I = 0.0025

1.479 (1.051-2.081)

0.024

M (L/L)

3 (1)

2 (0.6)

6 (1.9)

10 (3.1)

0.665 (0.11-4.004)

0.653