Skip to main content

Table 1 In vitro activity of chloroquine, quinine, mefloquine, monodesethylamodiaquine, lumefantrine, pyrimethamine, atovaquone, dihydroartemisinin and doxycycline against 36 strains of Plasmodium falciparum under controlled incubator conditions (10% O2) and Genbag® conditions (15% O2)

From: Use of the atmospheric generators for capnophilic bacteria Genbag-CO2 for the evaluation of in vitro Plasmodium falciparum susceptibility to standard anti-malarial drugs

Compound O2% IC50 t-test p-value
   Geometric mean 95%CI Min Max  
Chloroquine 10 127 nM 77-211 8 1032 <0.0001
  15 94 nM 61-146 12 751  
Quinine 10 580 nM 451-745 153 1752 <0.0001
  15 439 nM 336-573 96 1288  
Mefloquine 10 57.5 nM 50.7-65.3 30.8 131.0 0.0011
  15 49.7 nM 44.0-46.3 26.4 113.0  
Monodesethylamodiaquine 10 41.4 nM 28.8-59.6 4.7 379 <0.0001
  15 31.8 nM 21.8646.2 4.0 357  
Lumefantrine 10 23.8 nM 19.6628.8 7.1 65.0 0.0044
  15 21.2 nM 17.5-25.7 7.2 72  
Pyrimethamine 10 273 nM 88-852 10 17025 0.0902
  15 222 nM 67-735 10 14938  
Atovaquone 10 1.2 nM 0.8-1.8 0.1 7.3 0.0011
  15 2.1 nM 1.6-2.8 0.2 11.7  
Dihydroartemisinin 10 2.4 nM 2.0-2.9 1.2 10.8 0.4088
  15 2.4 nM 1.9-2.9 1.0 14.3  
Doxycycline 10 10.9 μM 9.8-12.1 7.6 26.0 0.6771
  15 10.8 μM 9.5-12.2 6.3 24.5  
cpm 10 2738 2628-2852 671 17845 <0.0001
  15 2282 2189-2379 623 12726