Table 1 In vitro activity of chloroquine, quinine, mefloquine, monodesethylamodiaquine, lumefantrine, pyrimethamine, atovaquone, dihydroartemisinin and doxycycline against 36 strains of Plasmodium falciparum under controlled incubator conditions (10% O2) and Genbag® conditions (15% O2)
Compound | O2% | IC50 | t-test p-value | |||
|---|---|---|---|---|---|---|
Geometric mean | 95%CI | Min | Max | |||
Chloroquine | 10 | 127 nM | 77-211 | 8 | 1032 | <0.0001 |
15 | 94 nM | 61-146 | 12 | 751 | ||
Quinine | 10 | 580 nM | 451-745 | 153 | 1752 | <0.0001 |
15 | 439 nM | 336-573 | 96 | 1288 | ||
Mefloquine | 10 | 57.5 nM | 50.7-65.3 | 30.8 | 131.0 | 0.0011 |
15 | 49.7 nM | 44.0-46.3 | 26.4 | 113.0 | ||
Monodesethylamodiaquine | 10 | 41.4 nM | 28.8-59.6 | 4.7 | 379 | <0.0001 |
15 | 31.8 nM | 21.8646.2 | 4.0 | 357 | ||
Lumefantrine | 10 | 23.8 nM | 19.6628.8 | 7.1 | 65.0 | 0.0044 |
15 | 21.2 nM | 17.5-25.7 | 7.2 | 72 | ||
Pyrimethamine | 10 | 273 nM | 88-852 | 10 | 17025 | 0.0902 |
15 | 222 nM | 67-735 | 10 | 14938 | ||
Atovaquone | 10 | 1.2 nM | 0.8-1.8 | 0.1 | 7.3 | 0.0011 |
15 | 2.1 nM | 1.6-2.8 | 0.2 | 11.7 | ||
Dihydroartemisinin | 10 | 2.4 nM | 2.0-2.9 | 1.2 | 10.8 | 0.4088 |
15 | 2.4 nM | 1.9-2.9 | 1.0 | 14.3 | ||
Doxycycline | 10 | 10.9 μM | 9.8-12.1 | 7.6 | 26.0 | 0.6771 |
15 | 10.8 μM | 9.5-12.2 | 6.3 | 24.5 | ||
cpm | 10 | 2738 | 2628-2852 | 671 | 17845 | <0.0001 |
15 | 2282 | 2189-2379 | 623 | 12726 | ||