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Table 2 Ratio based on the chloroquine-susceptible reference clone 3D7 (strain IC50/3D7 IC50) of chloroquine, quinine, mefloquine, monodesethylamodiaquine, lumefantrine, pyrimethamine, atovaquone, dihydroartemisinin and doxycycline against 36 strains of Plasmodium falciparum under controlled incubator conditions (10% O2) and Genbag® conditions (15% O2)

From: Use of the atmospheric generators for capnophilic bacteria Genbag-CO2 for the evaluation of in vitro Plasmodium falciparum susceptibility to standard anti-malarial drugs

Compound O2% IC50/3D7 IC50 t-test p-value
   Geometric mean 95%CI Min Max  
Chloroquine 10 6.88 4.15-11.41 0.40 55.80 <0.0001
  15 4.80 3.09-7.45 0.60 38.30  
Quinine 10 2.44 1.90-3.13 0.65 7.39 0.2418
  15 2.63 2.04-3.40 0.66 7.24  
Mefloquine 10 0.72 0.63-0.82 0.39 1.64 <0.0001
  15 0.91 0.81-1.03 0.49 2.089  
Monodesethylamodiaquine 10 2.59 1.80-3.72 0.29 23.69 0.5948
  15 2.52 1.73-3.67 0.32 28.33  
Lumefantrine 10 0.90 0.74-1.09 0.27 2.45 0.0119
  15 0.81 0.67-0.98 0.28 2.76  
Pyrimethamine 10 27.31 8.75-85.21 1.00 1703 0.0835
  15 18.01 5.51-58.82 1.00 1494  
Atovaquone 10 0.88 0.59-1.31 0.07 5.20 0.9187
  15 0.89 0.67-1.19 0.08 4.96  
Dihydroartemisinin 10 1.53 1.27-1.85 0.74 6.79 0.0006
  15 1.31 1.04-1.64 0.54 7.94  
Doxycycline 10 1.21 1.09-1.35 0.85 2.90 0.0002
  15 1.37 1.21-1.55 0.80 3.11