Table 3 Ratio based on the chloroquine-resistant reference clone W2 (strain IC₅₀/W2 IC₅₀) of chloroquine, quinine, mefloquine, monodesethylamodiaquine, lumefantrine, pyrimethamine, atovaquone, dihydroartemisinin and doxycycline against 36 strains of Plasmodium falciparum under controlled incubator conditions (10% O₂) and Genbag^® conditions (15% O₂)

Chloroquine

10

0.26

0.16-0.43

0.02

2.12

0.0014

15

0.21

0.14-0.33

0.03

1.71

Quinine

10

0.71

0.56-0.90

0.19

2.04

0.0006

15

0.56

0.43-0.74

0.12

1.65

Mefloquine

10

0.97

0.66-1.42

0.43

1.82

0.6262

15

0.82

0.72-0.92

0.43

1.85

Monodesethylamodiaquine

10

0.49

0.34-0.70

0.06

4.47

<0.0001

15

0.37

0.25-0.54

0.05

4.14

Lumefantrine

10

1.25

1.03-1.52

0.37

3.42

<0.0001

15

0.94

0.78-1.15

0.32

3.21

Pyrimethamine

10

0.03

0.01-0.10

0.001

1.96

0.0026

15

0.02

0.01-0.07

0.0008

1.26

Atovaquone

10

0.65

0.44-0.97

0.05

3.85

0.8646

15

0.67

0.50-0.89

0.06

3.71

Dihydroartemisinin

10

1.06

0.88-1.28

0.51

4.70

<0.0001

15

1.55

1.24-1.94

0.65

9.41

Doxycycline

10

1.16

1.05-1.29

0.81

2.78

0.0159

15

1.25

11.10-1.42

0.73

2.85