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Table 3 Ratio based on the chloroquine-resistant reference clone W2 (strain IC50/W2 IC50) of chloroquine, quinine, mefloquine, monodesethylamodiaquine, lumefantrine, pyrimethamine, atovaquone, dihydroartemisinin and doxycycline against 36 strains of Plasmodium falciparum under controlled incubator conditions (10% O2) and Genbag® conditions (15% O2)

From: Use of the atmospheric generators for capnophilic bacteria Genbag-CO2 for the evaluation of in vitro Plasmodium falciparum susceptibility to standard anti-malarial drugs

Compound O2% IC50/W2 IC50 t-test p-value
   Geometric mean 95%CI Min Max  
Chloroquine 10 0.26 0.16-0.43 0.02 2.12 0.0014
  15 0.21 0.14-0.33 0.03 1.71  
Quinine 10 0.71 0.56-0.90 0.19 2.04 0.0006
  15 0.56 0.43-0.74 0.12 1.65  
Mefloquine 10 0.97 0.66-1.42 0.43 1.82 0.6262
  15 0.82 0.72-0.92 0.43 1.85  
Monodesethylamodiaquine 10 0.49 0.34-0.70 0.06 4.47 <0.0001
  15 0.37 0.25-0.54 0.05 4.14  
Lumefantrine 10 1.25 1.03-1.52 0.37 3.42 <0.0001
  15 0.94 0.78-1.15 0.32 3.21  
Pyrimethamine 10 0.03 0.01-0.10 0.001 1.96 0.0026
  15 0.02 0.01-0.07 0.0008 1.26  
Atovaquone 10 0.65 0.44-0.97 0.05 3.85 0.8646
  15 0.67 0.50-0.89 0.06 3.71  
Dihydroartemisinin 10 1.06 0.88-1.28 0.51 4.70 <0.0001
  15 1.55 1.24-1.94 0.65 9.41  
Doxycycline 10 1.16 1.05-1.29 0.81 2.78 0.0159
  15 1.25 11.10-1.42 0.73 2.85