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Table 1 Anti-plasmodial activity, cytotoxicity and selectivity indexes of extracts IM, IMD and IMW

From: Icacina senegalensis (Icacinaceae), traditionally used for the treatment of malaria, inhibits in vitro Plasmodium falciparum growth without host cell toxicity

Extracts

IC50± SD* (μg/mL) for P. falciparum strains

IC50 (Hepa 1-6+)(μg/mL)

IC50 (NHDF+)(μg/mL)

SI

 

3D7

7G8

   

IM

4.7 ± 0.2

8 ± 1

133 ± 20

> 500

> 106

IMD

0.9 ± 0.2

4.1 ± 0.1

122 ± 4

> 500

> 500

IMW

14.2 ± 0.7

32 ± 2

447 ± 16

> 500

> 35

Chloroquine (nM)

44 ± 1

658 ± 14

> 800

> 800

> 18

  1. * Standard deviation
  2. +NHDF: Normal Human Dermal Fibroblasts
  3. +Hepa 1-6: Mouse hepatocytes
  4. IM: Methanol extract of I. senegalensis leaf extract, IMD: Apolar fraction of IM
  5. IMW: Polar fraction of IM, SI: selectivity index.