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Figure 1 | Malaria Journal

Figure 1

From: Natural products as starting points for future anti-malarial therapies: going back to our roots?

Figure 1

A high level scheme for identifying natural products based on ethnopharmacology. A high level scheme for identifying natural products based on ethnopharmacology. Screening strategies should be led by the initial confirmation that extracts have pharmacological activity at some level in the human disease and a clear absence of acute adverse events. Confirmation of such safety and efficacy from more than one study and community would be an advantage. Such a scheme would focus natural products research, prioritising those with confirmed activity in man. This process is an updated version of Yu Yunxiu’s 1952 doa-xing-ni-shi (acting in the reversed order) or 54321 [25]

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