Table 1 IC50 (ng/ml) of cinchona alkaloids in vitro against two clones of P. falciparum (cultured in erythrocytes suspended in RPMI medium supplemented with 10% AB serum and [3H]hypoxanthine) [23]
Alkaloid | UPASx1 clone1 | UPASx3 clone2 |
|---|---|---|
Quinine | 45 | 280 |
Quinidine | 22 | 80 |
Cinchonine | 27 | 130 |
Quinine + Quinidine + Cinchonine (equal parts) | 33 | 25 |
ΣFIC (<0.5 indicates significant synergy) | 1.15 | 0.18 |