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Table 1 IC50 (ng/ml) of cinchona alkaloids in vitro against two clones of P. falciparum (cultured in erythrocytes suspended in RPMI medium supplemented with 10% AB serum and [3H]hypoxanthine) [23]

From: Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

Alkaloid UPASx1 clone1 UPASx3 clone2
Quinine 45 280
Quinidine 22 80
Cinchonine 27 130
Quinine + Quinidine + Cinchonine (equal parts) 33 25
ΣFIC (<0.5 indicates significant synergy) 1.15 0.18
  1. 1 = quinine-sensitive
  2. 2 = quinine-resistant.