Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants?

Malaria Journal

Table 6 Calculation of the RITAM score for Vernonia amygdalina leaf decoction

Component of Score	Parameter	Value	Reference	Score
Ethnobotanical	Citation scores (see table1for details of calculation)		[40]	0.5
			[41]	0.6
			[42]	0.9
			[43]	0.6
			[44]	0.6
			[45]	0.5
			[46]	0.5
			[47]	0.8
Efficacy	IC₅₀in vitro	76.7 µg/ml	[48]	0
Efficacy	% inhibition in vivo	62.7%	[49]	6
Safety	LD₅₀	3320mg/kg	[50]	6
TOTAL				17

ISSN: 1475-2875