A “reverse pharmacology” approach for developing an anti-malarial phytomedicine

Malaria Journal

Table 2 In vitro anti-malarial activity of plant extracts identified in a retrospective treatment-outcome study, for plants with aqueous extracts having IC50 <10 μg/ml [12]

Plant	Plant part	Extract	IC₅₀ (μg/ml)
*Argemone mexicana*	Aerial parts	Methanol	1.00
*Argemone mexicana*	Aerial parts	Dichloromethane	1.22
*Argemone mexicana*	Aerial parts	Aqueous decoction	5.89
*Argemone mexicana*	Aerial parts	Aqueous maceration	6.22
*Opilia celtidifolia*	Bark	Aqueous maceration	7.64
*Spondias mombin*	Leaves	Aqueous maceration	7.66
*Securinega virosa*	Leaves	Aqueous decoction	7.81
*Spondias mombin*	Leaves	Aqueous decoction	7.89
*Cassia sieberiana*	Roots	Aqueous maceration	7.93
*Canthium acutiflorum*	Leaves	Aqueous maceration	8.09
*Securinega virosa*	Roots	Aqueous decoction	8.69
*Opilia celtidifolia*	Bark	Maceration in warm water then decoction	9.07
*Feretia apodanthera*	Bark	Aqueous decoction	9.54
*Securinega virosa*	Roots	Aqueous maceration	9.68
*Canthium acutiflorum*	Bark	Aqueous decoction	9.73

ISSN: 1475-2875