Table 5 Oucomes of treatment of uncomplicated malaria by a village health worker with Argemone mexicana decoction (AM ) or Artemisinin Combination Therapy (ACT ) as first-line anti-malarial (% and 95%CI)[35].
From: A “reverse pharmacology” approach for developing an anti-malarial phytomedicine
AM group | ACT group | |
|---|---|---|
No need for 2nd line treatment | 89.3% (84.1 – 93.2) | 95% (88.8 – 98.3) |
T <37.5°C (**) at day 14 | 93.9 (89.3 - 96.7) | 97.0 (91.6 – 99.4) |
T <37.5°C at day 28 | 96.9 (93.5 – 98.9) | 99.0 (94.6 – 100.0) |
Severe malaria >5yo | 0 (0 - 1.83) | 0 (0 - 3.62) |
Severe malaria (0-5 yo) | 1.9% (0.2 – 6.7) | 1.9% (0.05 – 10.3) |
Severe malaria (all ages) - Coma / convulsions | 0 (0 - 1.83) | 0 (0 - 3.62) |
Adverse effects | 14.2% (9.7 - 19.9)* | 18.8% (11.7 - 27.8)* |
New episode (day 15-28) (parasite positive) | 12.8% (8.4 – 18.3) | 9.9% (4.9 – 17.5) |