Skip to main content

Table 5 Oucomes of treatment of uncomplicated malaria by a village health worker with Argemone mexicana decoction (AM ) or Artemisinin Combination Therapy (ACT ) as first-line anti-malarial (% and 95%CI)[35].

From: A “reverse pharmacology” approach for developing an anti-malarial phytomedicine

  AM group ACT group
No need for 2nd line treatment 89.3% (84.1 – 93.2) 95% (88.8 – 98.3)
T <37.5°C (**) at day 14 93.9 (89.3 - 96.7) 97.0 (91.6 – 99.4)
T <37.5°C at day 28 96.9 (93.5 – 98.9) 99.0 (94.6 – 100.0)
Severe malaria >5yo 0 (0 - 1.83) 0 (0 - 3.62)
Severe malaria (0-5 yo) 1.9% (0.2 – 6.7) 1.9% (0.05 – 10.3)
Severe malaria (all ages) - Coma / convulsions 0 (0 - 1.83) 0 (0 - 3.62)
Adverse effects 14.2% (9.7 - 19.9)* 18.8% (11.7 - 27.8)*
New episode (day 15-28) (parasite positive) 12.8% (8.4 – 18.3) 9.9% (4.9 – 17.5)
  1. * Most common adverse effects : Cough and diarrhoea with AM, vomiting with ACT
  2. ** Temperature in degree Celsius