Skip to main content

Table 1 Molecular markers of resistance (%)

From: Molecular markers in Plasmodium falciparum linked to resistance to anti-malarial drugs in samples imported from Africa over an eight-year period (2002-2010): impact of the introduction of artemisinin combination therapy

n = 200

 

I

2002-2005

(n = 139)

II

2008-2010

(n = 61)

 

I

II

I

II

 

W

M

W

M

p

Combined genotypes

pfdhfr- 51

4.3

95.7

8.2

91.8

0.3

pfdhfr -51I-59R-108N

Cuadruple pfdhf-pfdps

pfdhfr- 59

5

95

8.2

91.8

0.5

  

51I-59R-108N-437G

pfdhfr- 108

1.4

98.6

1.6

98.4

1

90.8

81.3

53.4

63.3

pfdhfr- 164

100

0

100

0

1

  

Quintuple pfdhf-pfdps

pfdhps- 436

87.7

12.3

100

0

0.004

pfdhps -437G

51I-59R-108N-437G-540E

pfdhps- 437

29

71

16.4

83.6

0.05

  

18.4

16.3

pfdhps- 540

75.4

24.6

83.3

16.7

0.2

46.7

60

51I-59R-108N-437G-581G

pfdhps- 581

97.8

2.2

90

10

0.02

  

1

8.2

pfmdr1- 86

48.5

51.5

58.6

41.4

0.1

    

pfmdr1- 1246

64.9

35.1

91.8

8.2

0.0001

    

pfcrt- 76

4.4

95.6

3.4

96.6

1

    
  1. Wild-type (W) and mutant-type (M) alleles; I: 2002-2006; II: 2008-2010