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Table 5 Complications

From: Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and Belgium

Complication Number of patients (%) Recovery*
Haematological, n (%)   
   Abnormal bleeding 1 (2) Recovered
   Anemia 32 (47)  
hemolytic 7 (10) Recovered in all
severe (Hb< 3.6 mmol/l) 2 (3) Recovered in all
moderately severe (3.7 - 6.1 mmol/l) 23 (34) Recovered in 11/11
   Thrombocytopenia (< 20 giga/L) 16 (24) Recovered in all
   Hemoglobinuria 1 (2) Recovered
Hepatobiliary, n (%)   
   Elevated liver enzymes (LDH > 2x URL) 31 (46) Recovery in 14/14
Renal, n (%)   
   Acute renal insufficiency 7 (10) Recovered in 5/5
   Acute tubular necrosis 1 (2) Recovered
   Anuria 1 (2) Not resolved, still in need of dialysis
   Elevated creatinine levels (> 20% above URL) 9 (13) Recovered in 4/4
Nervous system, n (%)   
   Anal sphincter dysfunction 1 (2) Recovered
   Aphasia 1 (2) Recovered
   Cerebral edema 1 (2) Recovered
   Coma 2 (3) Recovered
   Convulsion 3 (4) Recovered
   Delirium 2 (3) Recovered in 1/2 §
   Diplopia 1 (2) Restoring but lost to follow up
   Neurological deficit 1 (2) Recovered
Truncal ataxia 1 (2) Restoring but lost to follow up
Cardiovascular, n (%   
   Arterial hypertension 1 (2) Recovered
   Atrial flutter 2 (3) Recovered
   AV Block (1st degree) 1 (2) Recovered
   Prolonged QTc interval 1 (2) Recovered
   Sinus bradycardia 1 (2) Recovered
   Supraventricular tachycardia 1 (2) Recovered
   Thrombophlebitis 2 (3) Recovered
Respiratory, n (%)   
   Exercise induced dyspnea 1 (2) Recovered
   Pneumonia 4 (6) Recovered
   Respiratory insufficiency 4 (6) Recovered
Other, n (%)   
   Deafness 3 (4) Recovered in 2/3
   Diarrhoea 3 (4) Recovered
   Fever 1 (2) Recovered
   Furunculosis 1 (2) Recovered
   Hypoglycaemia 1 (2) Recovered
   Peri-anal abcess 1 (2) Recovered
   Rash 2 (3) Recovered
   Reactive arthritis 1 (2) Recovered
   Sepsis 1 (2) Recovered
   Tropical ulcers 1 (2) Recovered
  1. URL: Upper reference limit reported by laboratory of admitting hospital
  2. * Number of patients that completely recovered/number of patients of whom data was complete (adequate follow up)
  3. characterized by increased reticulocyte counts, unconjugated bilirubin and lactate dehydrogenase and decreased haptoglobin and haemoglobin (Hb) values. See Table 6 for further details
  4. ‡ complication restoring in the remaining patients but patients were not followed until complete recovery (incomplete data)
  5. § the other patient died
  6. patient received pacemaker
  7. right ear remains deaf in one patient