Figure 1

Light microscopy of brain tissue obtained from children dying from cerebral malaria due to mixed Plasmodium falciparum/Plasmodium vivax infections. In panel A (Patient 1), occasional mature forms of P. falciparum were seen (Giemsa, magnification × 400). In panel B (Patient 2), malaria pigment and numerous P. falciparum trophozoites and schizonts are visible within the microvasculature (Giemsa, magnification x400). In panel C (Patient 3), there is acute chromatolysis of neurons and early infiltration by neutrophils from adjacent vessels at the edge of an area of infarction. The cerebral blood vessel (lower left) was normal and no malaria parasites were seen (H&E, magnification × 400).