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Table 1 Overview of the polymorphisms genotyped in the African population

From: Genetic variations in genes involved in heparan sulphate biosynthesis are associated with Plasmodium falciparum parasitaemia: a familial study in Burkina Faso

SNP Id a

SNP rs#

GRCh37 location (bp)

Localization within gene

Alleles b

MAF c

Molecular change

 

rs1047933

13399333

HS3ST3A1 3'UTR

T > A

-

-

 

rs67951062

13399487

HS3ST3A1 3'UTR

- > TTT

-

-

 

rs11385090

13399495

HS3ST3A1 3'UTR

A > -

-

-

 

rs67556828

13399497

HS3ST3A1 3'UTR

- > T

-

-

 

rs56160453

13399536

HS3ST3A1 ex2

A > G

-

mis-sense H [His] ⇒ R [Arg]

 

rs56184152

13399569

HS3ST3A1 ex2

C > T

-

mis-sense P [Pro] ⇒ L [Leu]

1

rs62057033

13399616

HS3ST3A1 ex2

T > A

0.069

Synonymous

 

rs55688668

13399778

HS3ST3A1 ex2

G > A

-

Synonymous

 

rs56408399

13399795

HS3ST3A1 ex2

C > T

-

mis-sense R [Arg] ⇒ W [Trp]

 

rs61729712

13399884

HS3ST3A1 ex2

G > A

-

mis-sense S [Ser] ⇒ N [Asn]

2

rs61732181

13399928

HS3ST3A1 ex2

G > A

0.043

Synonymous

 

rs55888783

13400004

HS3ST3A1 ex2

A > G

-

mis-sense D [Asp] ⇒ G [Gly]

 

rs56307410

13400014

HS3ST3A1 ex2

G > A

-

missense V [Val] ⇒ M [Met]

3

rs61744056

13400057

HS3ST3A1 ex2

C > T

0.005

Synonymous

4

rs8080565

13400153

HS3ST3A1 intron

C > T

0.106

-

 

rs60532842

13504194

HS3ST3A1 ex1

C > A

-

mis-sense A [Ala] ⇒ S [Ser]

 

rs28663356

13504408

HS3ST3A1 ex1

C > A

-

Synonymous

 

rs73298111

13504474

HS3ST3A1 5'UTR

C > T

-

-

5

rs3744337

13504665

HS3ST3A1 5'UTR

C > T

0.330

-

 

rs3744336

13504689

HS3ST3A1 5'UTR

A > T

-

-

 

rs34011501

13504833

HS3ST3A1 5'UTR

- > T

-

-

6

rs3744335

13504884

HS3ST3A1 5'UTR

A > C

0.320

-

7

rs28470223

13505023

HS3ST3A1 5'UTR

C > T

0.161

-

8

rs78863672

13505237

HS3ST3A1 5'UTR

G > T

0.433

-

 

rs67848311

13505244

intergenic

C > -

-

-

 

rs58718148

13505245

intergenic

C > -

-

-

9

rs2072243

14204380

HS3ST3B1 5'UTR

C > T

0.150

-

10

rs2072242

14204410

HS3ST3B1 5'UTR

T > C

0.184

-

11

rs115229628

14204423

HS3ST3B1 5'UTR

G > A

0.097

-

 

rs72241295

14204547-14205186

HS3ST3B1 5'UTR → ex1

639 bp del

-

Large deletion

12

rs62636623

14205082

HS3ST3B1 ex1

G > C

0.020

mis-sense G [Gly] ⇒ R [Arg]

13

rs62636622

14205168

HS3ST3B1 ex1

G > A

0.021

Synonymous

14

rs62056073

14248376

HS3ST3B1 ex2

A > G

0.009

mis-sense I [Ile] ⇒ V [Val]

15

rs9906855

14248423

HS3ST3B1 ex2

C > T

0.173

synonymous

 

rs56307410

14248466

HS3ST3B1 ex2

G > A

-

mis-sense V [Val] ⇒ M [Met]

 

rs55888783

14248476

HS3ST3B1 ex2

A > G

-

mis-sense D [Asp] ⇒ G [Gly]

 

rs61732181

14248552

HS3ST3B1 ex2

G > T/C

-

synonymous

16

rs61729712

14248596

HS3ST3B1 ex2

G > A

0.006

mis-sense S [Ser] ⇒ N [Asn]

 

rs56408399

14248685

HS3ST3B1 ex2

C > T

-

mis-sense R [Arg] ⇒ W [Trp]

17

rs55688668

14248702

HS3ST3B1 ex2

G > A

0.066

synonymous

 

rs61741326

14248864

HS3ST3B1 ex2

T > A

-

synonymous

18

rs9906590

14248877

HS3ST3B1 ex2

G > A

0.098

mis-sense E [Glu] ⇒ K [Lys]

 

rs56184152

14248911

HS3ST3B1 ex2

C > T

-

mis-sense P [Pro] ⇒ L [Leu]

 

rs56160453

14248944

HS3ST3B1 ex2

A > G

-

missense H [His] ⇒ R [Arg]

19

rs3785655

14249167

HS3ST3B1 3'UTR

C > T

0.059

-

20

rs7379332

14249433

HS3ST3B1 3'UTR

C > T

0.070

-

  1. aDetected SNPs are shown. bMajor allele > minor allele. cAllele frequency that was calculated in the study population is shown
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Malaria Journal

ISSN: 1475-2875

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