Table 1 Frequency of mutations and/or gene amplification in anti-malarial resistance markers pfmdr1 and pfcrt in Plasmodium falciparum isolates in Yaoundé and Mfou, Cameroon

pfmdr1 amplification (n^a = 215, n^b = NA)

   1 pfmdr1 copy number

215

(100%)

215

(100%)

NA

NA

NA

   > 1 pfmdr1 copy number

0

(0%)

0

(0%)

NA

NA

pfmdr1 codon 86 (n^a = 201, n^b = 209)

   Mutant 86Y haplotype only

328

(80%)

153

(76%)

175

(84%)

NS

   Mixed N86 and 86Y haplotypes

53

(13%)

28

(14%)

25

(12%)

   Wild-type N86 haplotype only

29

(7%)

20

(10%)

9

(4%)

   Total mutant 86Y haplotype^c

381

(93%)

181

(90%)

200

(96%)

0.042 ^d

pf c rt codon 76 (n^a = 203, n^b = 229)

   Mutant 76T haplotype only

270

(62%)

145

(71%)

125

(55%)

< 0.001^e

   Mixed K76 and 76T haplotypes

89

(21%)

20

(10%)

69

(30%)

   Wild-type K76 haplotype only

73

(17%)

38

(19%)

35

(15%)

   Total mutant 76T haplotype^c

359

(83%)

165

(81%)

194

(85%)

NS ^d

pf c rt codon 72 (n^a = 202, n^b = 212)

   Mutant 72S haplotype

0

(0%)

0

(0%)

0

(0%)

NS

   Wild-type C72 haplotype

414

(100%)

202

(100%)

212

(100%)