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Figure 2 | Malaria Journal

Figure 2

From: Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections

Figure 2

Association of elevated pfmdr1 copy number coupled with the presence or absence of the pfatp6 haplotype (A623E/S769N) and IC 50 values for artemether. Mean individual IC50 values are shown for non-mutant (pfatp6 A623/S769 and a pfmdr1 copy number of 1 (CN1), open circles) and mutant parasite isolates containing either pfatp6 623E/769 N and a pfmdr1 copy number of 1 (closed squares), pfatp6 A623/S769 and a pfmdr1 copy number of 2 (CN2, closed triangles) or pfatp6 623E/769 N and a pfmdr1 copy number of 2 (closed diamonds). The horizontal lines illustrate the mean IC50 values for each group, with 95% CI values of 5.9-11.6, -4.3-15.5, 5.2-15.4 and 10.7 to 21.8 for A623/S769/CN1, A623/S769/CN2, 623E/769 N/CN1 and 623E/769 N/CN2, respectively. **, p = 0.0068; *, p = 0.02.

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Malaria Journal

ISSN: 1475-2875

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