3D models of (A) PfATP6 and (B) PfMDR1. (A) S769 is highlighted in red. The first (K568) and last (C677) residues flanking the disordered region (which hosts A623) are reported in blue. Notice that the inset presents a zoom of the N domain rotated by 180° (in order to show the position of the disordered insertion, which is not visible in the model on the left). The predicted artemether binding region is in yellow. The beta-strand connecting the ATP-binding site to S769 is in green. (B) Blind docking poses for artemisinin, artesunate, DHA, and artemether are presented as filled spheres. SNPs are highlighted in red sticks. The known drug-binding site is shaded in red.