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Table 2 Pharmacokinetic parameters of artesunate and dihydroartemisinin

From: Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults

Parameter Artesunate Dihydroartemisinin
  Median (range) Median (range)
Dose (mg) 140 (111–190) 103 (82–140)
Cmax (ng/mL) 3260 (1020–164000) 3140 (1670–9530)
Tmax (hr) 0.25 (0–6.07) 0.14 (0–6.07)
CL (L/hr) 180 (1–652) 32.25 (16–55)
V (L) 68.5 (0.18–818) 59.7 (26–117)
T1/2 (hr) 0.25 (0.11–1.82) 1.31 (0.89–2.87)
AUC0-last (ng·h/mL) 727 (290–111256) 3492 (2183–6338)