Table 2 Pharmacokinetic parameters of artesunate and dihydroartemisinin
Parameter | Artesunate | Dihydroartemisinin |
|---|---|---|
Median (range) | Median (range) | |
Dose (mg) | 140 (111–190) | 103 (82–140) |
Cmax (ng/mL) | 3260 (1020–164000) | 3140 (1670–9530) |
Tmax (hr) | 0.25 (0–6.07) | 0.14 (0–6.07) |
CL (L/hr) | 180 (1–652) | 32.25 (16–55) |
V (L) | 68.5 (0.18–818) | 59.7 (26–117) |
T1/2 (hr) | 0.25 (0.11–1.82) | 1.31 (0.89–2.87) |
AUC0-last (ng·h/mL) | 727 (290–111256) | 3492 (2183–6338) |