Table 2 Temporal trends of additional dhps combinations from 1996 to 2009 by study period
dhps combinations | 1996-2000 (%) | 2002-2008 (%) | 2008-2009 (%) | P value |
|---|---|---|---|---|
S436A/F/H + A437G + K540E |  |  |  |  |
 Wild type | 44.4 | 1.7 | 0 |  |
 Single mutant | 25.6 | 1.7 | 0.8 | <0.001 |
 Double mutant | 30.0 | 94.3 | 93.2 |  |
 Triple mutant | 0 | 2.3 | 6.0 |  |
A437G + K540E + A581G |  |  |  |  |
 Wild type | 56.1 | 2.3 | 0 |  |
 Single mutant | 13.9 | 1.1 | 0.8 | <0.001 |
 Double mutant | 30.0 | 96.6 | 93.9 |  |
 Triple mutant | 0 | 0 | 5.3 |  |
S436A/F/H + A437G + K540E + A581G |  |  |  |  |
 Wild type | 44.4 | 1.7 | 0 |  |
 Single mutant | 25.6 | 1.7 | 0.8 | <0.001 |
 Double mutant | 30.0 | 94.3 | 88.5 |  |
 Triple mutant | 0 | 2.3 | 9.9 |  |
 Quadruple | 0 | 0 | 0.8 |  |