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Table 2 Temporal trends of additional dhps combinations from 1996 to 2009 by study period

From: Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western Kenya

dhps combinations 1996-2000
(%)
2002-2008
(%)
2008-2009
(%)
P value
S436A/F/H + A437G + K540E     
 Wild type 44.4 1.7 0  
 Single mutant 25.6 1.7 0.8 <0.001
 Double mutant 30.0 94.3 93.2  
 Triple mutant 0 2.3 6.0  
A437G + K540E + A581G     
 Wild type 56.1 2.3 0  
 Single mutant 13.9 1.1 0.8 <0.001
 Double mutant 30.0 96.6 93.9  
 Triple mutant 0 0 5.3  
S436A/F/H + A437G + K540E + A581G     
 Wild type 44.4 1.7 0  
 Single mutant 25.6 1.7 0.8 <0.001
 Double mutant 30.0 94.3 88.5  
 Triple mutant 0 2.3 9.9  
 Quadruple 0 0 0.8  
  1. P values derived from exact Pearson chi-square test. Mutated amino acids are depicted in bold font.