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Table 1 Percentage of patients whose Hb dropped by ≥2 g/dl (cases), by study site and risk factors

From: Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria

 

ΔHb ≥ 2 g/dl (%)

p-value*

Site

   

  Mozambique Manhiça

23.4

(49/209)

0.015

  Uganda Mbarara

23.8

(41/172)

 

  Uganda Tororo

8.6

(8/93)

 

  Uganda Jinja

19.6

(19/97)

 

Sex

   

  Boys

21.1

(64/303)

0.691

  Girls

19.8

(53/268)

 

Age, months

   

  12–27

35.3

(38/248)

0.026

  28–43

25.1

(51/203)

 

  44–60

23.3

(28/120)

 

Mild anaemia (Hb < 11 g/dl)

   

  Yes

13.9

(63/452)

<0.001

  No

45.4

(54/119)

 

Parasite density

   

  Low (<29623 μl-1)

15.5

(39/251)

0.034

  High (>29623 μl-1)

24.4

(78/320)

 

Treatment

   

  CDA

22.0

(42/191)

0.312

  AL

13.1

(8/61)

 

  DHAPQ

18.9

(36/190)

 

  AQ + AS

24.0

(31/129)

 
  1. CDA = chlorproguanil-daspone + artesunate. AL = artemether-lumefantrine. DHAPQ = dihydroartemisinin-piperaquine. AQ + AS = amodiaquine-artesunate.
  2. *Chi-square test.