Flow diagram showing the number of records retrieved, screened and included in this review article. Records were identified by searching publication and clinical trial databases. Duplicates were removed and the remaining records were screened based on their titles, abstracts or clinical trial information. Based on this screen, records judged not to feature any data on the subject of artemether or AL safety, efficacy or pharmacokinetics in human pregnancy were excluded. Of 57 full text articles assessed for eligibility, 39 articles were excluded as they did not include specific reports of artemether or AL exposures during pregnancy and two articles were excluded to avoid duplication of pregnancy exposures. Sixteen relevant articles were therefore identified and included in this review article *1948–2011; **English-language articles. All years; †All years; ICTRP, International Clinical Trials Registry Platform.