Table 3 Efficacy outcomes of artemether–lumefantrine use during pregnancy

McGready et al. , 2008[22]

Thai study. Open- label, randomized study of AL vs. AS in the 2^nd and 3^rd trimesters

AL (125)

2 (1–3) days^†

2 (1–5) days^†

87.2% (95% CI 81.1–93.2)^‡ at Day 42.82.0% (95% CI 74.8–89.3)^‡ at delivery (or Day 42 if later)

AS (128)

1 (1–2) days^†

2 (1–5) days^†

95.2% (95% CI 91.5–97.1)^‡ at Day 42.89.2% (95% CI 82.3–96.1)^‡ at delivery (or Day 42 if later)

Kaye et al. , 2008[23]

Ugandan study. Open-label, randomized study of AL vs. chlorproguanil-dapsone* in the 2^nd and 3^rd trimesters

AL (58)

47 (85.5%) clear at Day 2

49 (89.1%) clear at Day 2

100% at Day 28

Piola et al., 2010[25]

Ugandan study. Open-label, randomized study of AL vs. Q in the 2^nd and 3^rd trimesters

AL (152)

130 (100%) clear at Day 2

148 (99%) clear at Day 2

99.3% (range 96.0–99.9)^§ at Day 42.98.2% (range 93.5–99.7)^§ at delivery (or Day 42 if later)

Q (152)

127 (99%) clear at Day 2

123 (86%) clear at Day 2

97.6% (range 93.1–99.5)^§ at Day 42.96.1% (range 90.2–98.9)^§ at delivery (or Day 42 if later)