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Table 4 Results of bivariate and multivariate analysis of co-infected group and single dengue infection and single malaria infection respectively

From: Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana

 

Outcome

Bivariate analysis

Multivariate analysis

Sensitivity (%)

Specificity

(%)

OR*

95% CI*

p*

OR**

95% CI**

p**

Co-infection versus dengue

Confirmed acute dengue cases

5.3

2.9-9.7

<0.001

4.5

1.7-11.9

0.003

79.1

52.1

Males

1.9

1.2-3.2

0.01

3.4

1.1-10.3

0.03

38.7

75.4

Low hematocrit (<36%)

4.3

2.3-8.2

<0.001

8.4

2.2-32-5

0.002

53.5

74.3

Deep thrombocytopenia (<50. 10 9 /L)

13.8

4.1-46

<0.001

11.7

1.7-79.2

0.01

79.3

71.4

  CRP 5 to 50 mg/L

5.0

1.1-21.7

<0.001

5.3

0.9-29.3

0.06

-

-

  CRP >50 mg/L

75.4

16-356.7

<0.001

74.4

12.2-453.3

<0.001

78.4

85.8

Co-infection versus malaria

Red cells transfusion

7.3

1.5-34.7

0.01

5.3

1.04-26.7

0.04

72.7

68.1

Low hematocrit (<36%)

2.2

1.3-3.6

0.002

2

1.2-3.5

0.009

46.0

72.6

Deep thrombocytopenia (<50. 10 9 /L)

2.2

1.1-4.1

0.02

2.1

1.02-4.1

0.04

47.9

69.3

Low parasitic load (class < 3)

1.8

0.9-3.3

0.08

2.2

1.08-4.3

0.03

45.4

68.6

  1. * Odds ratio (OR) and 95% confidence interval (95% CI) and p calculated by matched bivariate analysis.
  2. ** Odds ratio and 95% confidence interval and p calculated by matched multivariate analysis.
  3. CRP C-reactive protein.